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PDE1B Monoclonal Antibody

  • 中文名稱(chēng)：
    PDE1B Monoclonal Antibody
  • 貨號(hào)：
    CSB-MA250158
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western blotting analysis using phosphodiesterase 1B antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with phosphodiesterase 1B antibody and HRP-conjugated goat mouse secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Mouse anti-Homo sapiens (Human) PDE1B Monoclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    PDE1B; Phosphodiesterase 1B; PDES1B; Dual Specificity Calcium/Calmodulin-Dependent 3',5'-Cyclic Nucleotide Phosphodiesterase 1B; Phosphodiesterase 1B, Calmodulin-Dependent; 63 KDa Cam-PDE; EC 3.1.4.17; Cam-PDE 1B; Presumed 63kDa Form Of The Type 1 Cyclic Nucleotide Phosphodiesterase Family Known As PDE1B; Calcium/Calmodulin-Dependent 3',5'-Cyclic Nucleotide Phosphodiesterase 1B; Calcium/Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase; Epididymis Secretory Sperm Binding Protein Li 79p; Calmodulin-Stimulated Phosphodiesterase PDE1B1; HEL-S-79p; EC 3.1.4; PDE1B1
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human PDE1B protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG2b
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    19G3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
  • 基因功能參考文獻(xiàn)：
    1. The c.1618G>A, p.Gly540Ser substitution in CNGA3 was identified as the causative mutation for a novel form of ACHM in Awassi sheep. Gene augmentation therapy restored vision in the affected sheep. This novel mutation provides a large-animal model that is valid for most human CNGA3 ACHM patients; the majority of them carry missense rather than premature-termination mutations. PMID: 28282490
    2. Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation. PMID: 15625104
    3. PDE1B2 regulates a subset of phenotypic changes that occur upon phorbol-12-myristate-13-acetate-induced differentiation and likely also plays a role in differentiated macrophages by regulating agonist-stimulated cGMP levels PMID: 16407168
  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family, PDE1 subfamily
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 8775

    OMIM: 171891

    KEGG: hsa:5153

    STRING: 9606.ENSP00000243052

    UniGene: Hs.530871