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PDCL3 Monoclonal Antibody

  • 中文名稱：
    PDCL3 Monoclonal Antibody
  • 貨號：
    CSB-MA061104
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Phosducin like 3 expression in HeLa cells using Phosducin like 3 antibody. Green, isotype control; red, Phosducin like 3.
    • Western blotting analysis using phosducin like 3 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with phosducin like 3 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) PDCL3 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    PDCL3
  • 別名：
    PDCL3; Phosducin Like 3; VIAF1; Viral IAP-Associated Factor 1; Phosducin-Like Protein 3; HTPHLP; VIAF-1; PhPL3; IAP-Associated Factor VIAF1; PHLP2A; PhLP2A; PHLP3; VIAF
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human PDCL3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG2a
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    10D11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
    FC 1:200-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes. Modulates the activation of caspases during apoptosis.
  • 基因功能參考文獻：
    1. results have shown that PhLP2A interacts with Hsp90 and exhibits molecular chaperone activity toward denatured proteins. PMID: 27496612
    2. The data provide new insights for the chaperone function of PDCL3 in angiogenesis and the roles of hypoxia and N-terminal methionine acetylation in PDCL3 expression and its effect on VEGFR-2. PMID: 26059764
    3. data provide strong evidence for the role of PDCL3 in angiogenesis and establishes the molecular mechanism by which it regulates VEGFR-2 expression and function. PMID: 23792958
    4. Data support a model in which Plp2p modulates the biogenesis of several CCT substrates relating to cell cycle and cytoskeletal function, which together contribute to the essential function of PLP2. PMID: 17429077
    5. This publication pertains to mouse. PMID: 12424248

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  • 亞細胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.
  • 蛋白家族：
    Phosducin family
  • 組織特異性：
    Expressed in endothelial cells (at protein level). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon.
  • 數據庫鏈接：

    HGNC: 28860

    OMIM: 611678

    KEGG: hsa:79031

    STRING: 9606.ENSP00000264254

    UniGene: Hs.469459