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  4. PACSIN3 Monoclonal Antibody

PACSIN3 Monoclonal Antibody

  • 中文名稱：
    PACSIN3 Monoclonal Antibody
  • 貨號(hào)：
    CSB-MA166593
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of PACSIN3 expression in HepG2 cells using PACSIN3 antibody. Green, isotype control; red, PACSIN3.
    • Immunocytochemical staining of HepG2 cells with PACSIN3 antibody. Nuclei were stained blue with DAPI; PACSIN3 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and Smart Gain：Low. Scale bar, 20 μm.
    • Western blotting analysis using PACSIN3 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with PACSIN3 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Mouse anti-Homo sapiens (Human) PACSIN3 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    PACSIN3
  • 別名：
    PACSIN3; Protein Kinase C And Casein Kinase Substrate In Neurons 3; SDPIII; Protein Kinase C And Casein Kinase Substrate In Neurons Protein 3; SH3 Domain-Containing Protein 6511; Syndapin III
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human PACSIN3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    23F9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:2500-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.
  • 基因功能參考文獻(xiàn)：
    1. Show that in neuroendocrine chromaffin cells fusion pore expansion and catecholamine release are limited specifically by mutation of syndapin 3. PMID: 24500282
    2. Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules PMID: 22573331
    3. PACSIN3 has a novel function as an up-regulator in the signaling of proHB-EGF shedding induced by TPA and angiotensin II PMID: 12952982
    4. PACSIN 3 acts as an auxiliary protein of TRPV4 channel that not only affects the channel's subcellular localization but also modulates its function in a stimulus-specific manner. PMID: 18174177
  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    PACSIN family
  • 組織特異性：
    Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 8572

    OMIM: 606513

    KEGG: hsa:29763

    STRING: 9606.ENSP00000298838

    UniGene: Hs.334639