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NME4 Monoclonal Antibody

  • 中文名稱:
    NME4 Monoclonal Antibody
  • 貨號:
    CSB-MA572333
  • 規格:
    ¥1320
  • 圖片:
    • Western blotting analysis using NME4 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with NME4 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他:

產品詳情

  • 產品名稱:
    Mouse anti-Homo sapiens (Human) NME4 Monoclonal antibody
  • Uniprot No.:
  • 基因名:
    NME4
  • 別名:
    NME4; NME/NM23 Nucleoside Diphosphate Kinase 4; Nm23-H4; NDPKD; NM23H4; Non-Metastatic Cells 4, Protein Expressed In; Nucleoside Diphosphate Kinase, Mitochondrial; Nucleoside Diphosphate Kinase D; NDP Kinase, Mitochondrial; EC 2.7.4.6; NDK; NDP Kinase D; NDPK-D; NM23D
  • 宿主:
    Mouse
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human NME4 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    Mouse IgG1
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    18A1
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis. Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity. Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration. Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria. In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling.
  • 基因功能參考文獻:
    1. NDPK-D has an important role in the early stages of mitophagy as induced by carbonyl cyanide m-chlorophenylhydrazone as well as by PINK1-Parkin-independent stimuli such as rotenone and 6-hydroxydopamine. PMID: 26742431
    2. Mitochondrial NM23-H4/NDPK-D: a bifunctional nanoswitch for bioenergetics and lipid signaling PMID: 25231795
    3. miR-196 performed it's their function by inhibiting NME4 expression and further activating p-JNK, suppressing TIMP1, and augmenting MMP1/9. PMID: 25233933
    4. Nm23-H4 acts as a lipid-dependent mitochondrial switch with dual function in phosphotransfer serving local GTP supply and cardiolipin transfer for apoptotic signaling and putative other functions PMID: 23150663
    5. High expression of ERCC1, FLT1, NME4 and PCNA in myelodysplastic syndrome was associated with poor prognosis and disease progression along the sequence of 5q-syndrome/RCMD/RAEB/de novo AML PMID: 18604718

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  • 亞細胞定位:
    Mitochondrion intermembrane space; Peripheral membrane protein. Mitochondrion matrix.
  • 蛋白家族:
    NDK family
  • 組織特異性:
    Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes.
  • 數據庫鏈接:

    HGNC: 7852

    OMIM: 601818

    KEGG: hsa:4833

    STRING: 9606.ENSP00000219479

    UniGene: Hs.9235