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KATNAL1 Monoclonal Antibody

  • 中文名稱：
    KATNAL1 Monoclonal Antibody
  • 貨號：
    CSB-MA034336
  • 規格：
    ￥1320
  • 圖片：
    • Western blotting analysis using KATNAL1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with KATNAL1 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) KATNAL1 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    KATNAL1
  • 別名：
    KATNAL1; Katanin Catalytic Subunit A1 Like 1; Katanin P60 ATPase-Containing Subunit A-Like 1; Katanin Catalytic Subunit A Like 1; Katanin P60 Subunit A-Like 1; Katanin P60 Subunit A Like 1; P60 Katanin-Like 1; MGC2599; EC 5.6.1.1; EC 3.6.4.3
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human KATNAL1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    3D5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays. Has microtubule-severing activity in vitro.
  • 基因功能參考文獻：
    1. microdeletion 13q12.3 represents a novel clinically recognizable condition and that the microtubule severing gene KATNAL1 and the chromatin-associated gene HMGB1 are candidate genes for intellectual disability inherited in an autosomal dominant pattern. PMID: 24664804
    2. KATNAL1 gene sequence variants are not associated with azoospermia. PMID: 24913027
    3. KL1-mediated microtubule severing is utilized to generate microtubule seeds within the poles and loss of this activity alters the normal balance of motor-generated forces that determine spindle length. PMID: 20519956
  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    AAA ATPase family, Katanin p60 subunit A1 subfamily, A-like 1 sub-subfamily
  • 組織特異性：
    Expressed in testis, restricted to Sertoli cells (at protein level).
  • 數據庫鏈接：

    HGNC: 28361

    OMIM: 614764

    KEGG: hsa:84056

    STRING: 9606.ENSP00000369989

    UniGene: Hs.243596