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HSD17B4 Monoclonal Antibody

  • 中文名稱：
    HSD17B4 Monoclonal Antibody
  • 貨號：
    CSB-MA120654
  • 規格：
    ￥1320
  • 圖片：
    • Validation of HSD17B4 knockdown using flow cytometry. Wild-type(WT, Blue) and knockdown(KD, Green) HeLa cells were stained with HSD17B4 antibody and analyzed using BD flow cytometer.
    • Western blotting analysis using HSD17B4 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with HSD17B4 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
    • Western blotting analysis using HSD17B4 antibody. HSD17B4 expression in wild-type (WT) and HSD17B4 shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with HSD17B4 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) HSD17B4 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    HSD17B4
  • 別名：
    HSD17B4; Hydroxysteroid 17-Beta Dehydrogenase 4; SDR8C1; MFE-2; DBP; 17-Beta-Hydroxysteroid Dehydrogenase 4; 3-Alpha,7-Alpha,12-Alpha-Trihydroxy-5-Beta-Cholest-24-Enoyl-CoA Hydratase; Short Chain Dehydrogenase/Reductase Family 8C Member 1; Peroxisomal Multifunctional Enzyme Type 2; 17beta-Estradiol Dehydrogenase Type IV; Peroxisomal Multifunctional Protein 2; D-Bifunctional Protein, Peroxisomal; D-3-Hydroxyacyl-CoA Dehydratase; Beta-Hydroxyacyl Dehydrogenase; Multifunctional Protein 2; Beta-Keto-Reductase; 17-Beta-HSD IV; 17-Beta-HSD 4; MFP-2; Short Chain Dehydrogenase/Reductase Family 8C, Member 1; Epididymis Secretory Sperm Binding Protein; Hydroxysteroid (17-Beta) Dehydrogenase 4; Hydroxysteroid Dehydrogenase 4; D-Bifunctional Protein; EDH17B4; PRLTS1; MPF-2
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human HSD17B4 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG2b
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    23A2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:400-1:2000
    FC 1:200-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from straight-chain, 2-methyl-branched-chain fatty acids bile acid intermediates. With EHHADH, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity.
  • 基因功能參考文獻：
    1. This study reveals a crosstalk between acetylation and chaperone-mediated autophagy degradation in HSD17B4 regulation. PMID: 28296597
    2. we identified that methylation of the promoter CpG island of HSD17B4 was associated with the pathological complete response of HER2-positive breast cancer to trastuzumab and chemotherapy with a specificity of 79% PMID: 28186977
    3. Our findings supported that HSD17B4 was one of the genes contributing to Perrault syndrome in this consanguineous Chinese Han family. PMID: 28830375
    4. ere we present eight families affected by Perrault syndrome. In five families we identified novel or previously reported variants in HSD17B4, LARS2, CLPP and C10orf2 PMID: 26970254
    5. Results show that HSD17B4 is highly expressed in hepatocellular carcinoma (HCC) cells and activated NF-kappaB co-localized with the NF-kappaB-responsive element of HSD17B4 suggesting that HSD17B4 plays an important role in aggravated HCC progression. PMID: 25448063
    6. Structural MFE-2 instability is the molecular basis of D-bifunctional protein deficiency type III. PMID: 23308274
    7. Specific combination of compound heterozygous mutations in 17beta-hydroxysteroid dehydrogenase type 4 (HSD17B4) defines a new subtype of D-bifunctional protein deficiency. PMID: 23181892
    8. Molecular models of domain structure of MFE-2 from human, C. elegans, and Drosophila melanogaster lend support to possible structural role of MFE-2 domains including SCP-2L (sterol carrier protein 2-like) domain in human and C. elegans proteins. PMID: 23313254
    9. Epistasis between the HSD17B4 and thyroglobulin polymorphisms is associated with premature ovarian failure. A haplotype in the HSD17B4 gene was identified that was significantly associated with resistance to POF PMID: 22265031
    10. The diagnosis of a type III DBPD with a missense mutation (T15A) in the HSD17B4 gene, coding for D-bifunctional protein (DBP), could be established. PMID: 20949532
    11. MFE2 anchors its substrate around the region from Trp(249) to Arg(251) and positions the substrate along the hydrophobic cavity in the proper direction toward the catalytic center PMID: 20566640
    12. Perrault syndrome and DBP deficiency overlap clinically and Perrault syndrome is genetically heterogeneous. PMID: 20673864
    13. rs11205 in HSD17B4 was associated with testicular germ cell tumor. Risk doubled per copy of the minor A allele. Homozygosity of this allele quadrupled the risk vs. homozygous major G allele. The risk was increased both for seminoma & nonseminoma. PMID: 19776291
    14. crystal structure of 2-enoyl-CoA hydratase 2 PMID: 15644212
    15. Deficiency of this enzyme in man causes a severe developmental syndrome with abnormalities in several organs but in particular in the brain, leading to death within the first year of life. PMID: 16766224
    16. HSD17B4 is not only associated with the presence of prostate cancer, but is also a significant independent predictor of poor patient outcome. PMID: 19100308
    17. HSD17B4 mRNA is expressed in human skin, at similar levels in men and women. HSD17B4 levels are not altered by topical 17-beta-estradiol treatment. PMID: 18794456

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  • 相關疾病：
    D-bifunctional protein deficiency (DBPD); Perrault syndrome 1 (PRLTS1)
  • 亞細胞定位：
    Peroxisome.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 組織特異性：
    Present in many tissues with highest concentrations in liver, heart, prostate and testis.
  • 數據庫鏈接：

    HGNC: 5213

    OMIM: 233400

    KEGG: hsa:3295

    STRING: 9606.ENSP00000420914

    UniGene: Hs.406861