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  4. HNRNPF Monoclonal Antibody

HNRNPF Monoclonal Antibody

  • 中文名稱：
    HNRNPF Monoclonal Antibody
  • 貨號：
    CSB-MA981178
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Heterogeneous nuclear ribonucleoprotein F expression in HepG2 cells using Heterogeneous nuclear ribonucleoprotein F antibody. Green, isotype control; red, Heterogeneous nuclear ribonucleoprotein F.
    • Immunocytochemical staining of HepG2 cells with Heterogeneous nuclear ribonucleoprotein F antibody. Nuclei were stained blue with DAPI; Heterogeneous nuclear ribonucleoprotein F was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and Smart Gain：Medium. Scale bar, 20 μm.
    • Western blotting analysis using heterogeneous nuclear ribonucleoprotein F antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with heterogeneous nuclear ribonucleoprotein F antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) HNRNPF Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    HNRNPF
  • 別名：
    HNRNPF; Heterogeneous Nuclear Ribonucleoprotein F; HNRPF; Nucleolin-Like Protein Mcs94-1; HnRNP F Protein; OK/SW-Cl.23; Mcs94-1; HnRNP F
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human HNRNPF protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG2a
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    9B1
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:2000-1:10000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.
  • 基因功能參考文獻：
    1. hnRNP H/F are important for maintenance and differentiation of embryonic stem cells and that this at least in part reflects a switch in TCF3 alternative splicing that leads to repression of CDH1/E-cadherin. PMID: 30115631
    2. Results from a study on gene expression variability markers in early-stage human embryos shows that HNRNPF is a putative marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    3. heterogeneous nuclear ribonucleoprotein F (hnRNPF) regulates G-quadruplex-associated alternative splicing across the transcriptome. PMID: 29269483
    4. Simulation results demonstrate that the RNA binding domain qRRM2 of hnRNP F binds strongly with G-tract RNA, but any mutation of the G-tract leads to a drastic reduction of the binding free energy. PMID: 29050934
    5. Human T2D kidneys exhibited more RPTC apoptosis and lower expression of hnRNP F, SIRTUIN-1, and FOXO3alpha than nondiabetic kidneys. PMID: 28424160
    6. hnRNP F is a co-factor in a subset of tristetraprolin/BRF1/BRF2-mediated mRNA decay. PMID: 24978456
    7. this result suggests that hnRNP F directs formation of the exon 4 minus variant of ENOX2. PMID: 21625959
    8. The study shows solution structures of the three quasi-RNA-recognition motifs of heterogeneous nuclear ribonucleoprotein F in complex with G-tract RNA. PMID: 20526337
    9. heterogeneous ribonucleoprotein F is involved in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway PMID: 20308064
    10. Results suggest that hnRNP H and F are nuclear shuttling proteins whose posttranslational modifications may alter interaction with transportin 1, nuclear localization, and hence function. PMID: 20308327
    11. high levels of hnRNP F are present in premalignant and malignant stages of colorectal cancer, reflecting a role for this protein early in colorectal tumorigenesis PMID: 16424007
    12. The solution structure of the three quasi RNA recognition motifs of hnRNP F and identification of the residues that are important for the interaction with the Bcl-x RNA. PMID: 16885237
    13. hnRNPH and F regulate DM20 splicing by recruiting U1snRNP and hnRNPH plays a primary role in DM20 splice site selection in vivo PMID: 19244236
    14. Shows that hnRNPF regulates the 3' end cleavage reaction. PMID: 11158309

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  • 亞細胞定位：
    Nucleus, nucleoplasm.
  • 組織特異性：
    Expressed ubiquitously.
  • 數據庫鏈接：

    HGNC: 5039

    OMIM: 601037

    KEGG: hsa:3185

    STRING: 9606.ENSP00000338477

    UniGene: Hs.712955