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GDI1 Monoclonal Antibody

  • 中文名稱：
    GDI1 Monoclonal Antibody
  • 貨號：
    CSB-MA238184
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of GDI1 expression in HAP-1 cells using GDI1 antibody. Green, isotype control; red, GDI1.
    • Western blotting analysis using GDI1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with GDI1 antibody and HRP-conjugated goat mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) GDI1 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    GDI1
  • 別名：
    GDI1; GDP Dissociation Inhibitor 1; RABGDIA; OPHN2; Oligophrenin-2; XAP-4; GDIL; Guanosine Diphosphate Dissociation Inhibitor 1; Rab GDP-Dissociation Inhibitor, Alpha; Rab GDP Dissociation Inhibitor Alpha; Protein XAP-4; Rab GDI Alpha; FLJ41411; MRX41; MRX48; GDI-1; Testis Secretory Sperm-Binding Protein Li 208a; Mental Retardation, X-Linked 41; Mental Retardation, X-Linked 48; RABGD1A; XLID41; XAP4; 1A
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human GDI1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    22F4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:200-1:1000
    FC 1:200-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.
  • 基因功能參考文獻：
    1. Data confirm isolated adrenocorticotropin deficiency (IAD) as autoimmune disease; RABGDIA (human, human recombinant, or rat) exhibits characteristics of autoantigen in anterior pituitary; patients with IAD exhibit autoantibodies against RABGDIA. PMID: 25346144
    2. Human oligodendrogliomas cells stably expressing mutant GDI1 showed altered cell proliferation. PMID: 25694352
    3. The results of this study identified RabGDI as a component of the switching mechanism that is required for commissural axons to change their response from attraction to repulsion at the intermediate target PMID: 23140504
    4. GDI1 mutations cause an unspecific phenotype characterized by cognitive deficits of variable degree in males, and to a lesser degree in female carriers. PMID: 22002931
    5. The mutations in this gene are common and do not seem to influence the gene expression so as to cause a change in phenotype. PMID: 21736009
    6. A model by which mutant PrP induces overexpression of GDI, activating a cytotoxic feedback loop that leads to protein accumulation in the secretory pathway. PMID: 19996123
    7. RhoGDI has a role in inactivating Rho GTPases with ExoS RhoGAP PMID: 15292224
    8. isoprenylcysteine carboxylmethyltransferase regulates Rac1 activity by controlling the interaction of Rac1 with RhoGDI through TNFA PMID: 15647276
    9. RhoGDI overexpression is associated with paclitaxel resistance in ovarian cancers PMID: 16596196
    10. The results of case-control analysis indicated that, no association between the rs11549300 polymorphisms of GDI1 and children NSMR (P >0.05), but its polymorphisms may be related to intelligence levels of children in Qinba region (P =0.03). PMID: 18487148
    11. GDI-1 is preferentially involved in insulin-stimulated glucose transporter 4 (GLUT4) translocation through facilitating Rab10 recycling. PMID: 19570034

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  • 相關疾病：
    Mental retardation, X-linked 41 (MRX41)
  • 亞細胞定位：
    Cytoplasm. Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    Rab GDI family
  • 組織特異性：
    Brain; predominant in neural and sensory tissues.
  • 數據庫鏈接：

    HGNC: 4226

    OMIM: 300104

    KEGG: hsa:2664

    STRING: 9606.ENSP00000394071

    UniGene: Hs.595950