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FBXO21 Monoclonal Antibody

  • 中文名稱：
    FBXO21 Monoclonal Antibody
  • 貨號(hào)：
    CSB-MA041523
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of FBXO21 expression in HAP-1 cells using FBXO21 antibody. Green, isotype control; red, FBXO21.
    • Western blotting analysis using FBXO21 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with FBXO21 antibody and HRP-conjugated goat mouse secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Mouse anti-Homo sapiens (Human) FBXO21 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    FBXO21
  • 別名：
    FBXO21; F-Box Protein 21; FBX21; F-Box Only Protein 21; KIAA0875
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human FBXO21 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG2a
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    13F2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
    FC 1:100-1:1000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
  • 基因功能參考文獻(xiàn)：
    1. Ser291-phosphorylated form of the multifunctional protein and stem cell marker, CD44, inhibits FBXO21-directed degradation of P-gp. PMID: 26299618
    2. SCF(FBXO21) polyubiquitylates EID1 both in vitro and in vivo and is required for the efficient degradation of EID1 in both cycling and quiescent cells. PMID: 26631746
    3. The results suggest that EID1 is a bona fide substrate of FBXO21 and that the control of EID1 abundance by SCF(FBXO)(21) might affect the transcriptional repression activity of EID1. PMID: 26085330
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 13592

    OMIM: 609095

    KEGG: hsa:23014

    STRING: 9606.ENSP00000328187

    UniGene: Hs.740376