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EIF2B3 Monoclonal Antibody

  • 中文名稱：
    EIF2B3 Monoclonal Antibody
  • 貨號：
    CSB-MA113666
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of EIF2B3 expression in C2C12 cells using EIF2B3 antibody. Green, isotype control; red, EIF2B3.
    • Western blotting analysis using EIF2B3 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with EIF2B3 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) EIF2B3 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    EIF2B3
  • 別名：
    EIF2B3; Eukaryotic Translation Initiation Factor 2B Subunit Gamma; EIF2Bgamma; EIF-2B; Eukaryotic Translation Initiation Factor 2B, Subunit 3 Gamma, 58kDa; Translation Initiation Factor EIF2B Subunit Gamma; EIF2B GDP-GTP Exchange Factor Subunit Gamma; Eukaryotic Translation Initiation Factor 2B, Subunit 3 (Gamma, 58kD); Translation Initiation Factor EIF-2B Subunit Gamma; EIF-2B GDP-GTP Exchange Factor Subunit Gamma; VWM3
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human EIF2B3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    8H12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
    FC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
  • 基因功能參考文獻：
    1. To determine the tolerance differences to ERS, cell viability and apoptosis rates were detected in oligodendrocyte cell lines transfected with EIF2B3-c.1037T>C or the wild type. We confirmed that oligodendrocytes with mutant EIF2B3 was less tolerant to ERS than the wild type, with decreased cell viability and increased apoptosis rates. PMID: 26625702
    2. Results show significant higher incidence of Chinese patients with EIF2B3 mutations compared with Caucasian patients. The c.1037T>C in EIF2B3 was confirmed to be a founder mutation in Chinese explaining the genotypic differences between ethnicities. PMID: 25761052
  • 相關疾病：
    Leukodystrophy with vanishing white matter (VWM)
  • 蛋白家族：
    EIF-2B gamma/epsilon subunits family
  • 數據庫鏈接：

    HGNC: 3259

    OMIM: 603896

    KEGG: hsa:8891

    STRING: 9606.ENSP00000353575

    UniGene: Hs.533549