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  4. DPYSL5 Monoclonal Antibody

DPYSL5 Monoclonal Antibody

  • 中文名稱：
    DPYSL5 Monoclonal Antibody
  • 貨號：
    CSB-MA128721
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Dihydropyrimidinase like 5 expression in HAP-1 cells using Dihydropyrimidinase like 5 antibody. Green, isotype control; red, Dihydropyrimidinase like 5.
    • Immunocytochemical staining of HAP1 cells with Dihydropyrimidinase like 5 antibody. Nuclei were stained blue with DAPI;Dihydropyrimidinase like 5 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using dihydropyrimidinase like 5 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with dihydropyrimidinase like 5 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) DPYSL5 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    DPYSL5
  • 別名：
    DPYSL5; Dihydropyrimidinase Like 5; CRMP-5; CRMP5; CRAM; Ulip6; CV2; Collapsin Response Mediator Protein 5; Dihydropyrimidinase-Related Protein 5; UNC33-Like Phosphoprotein 6; CRMP3-Associated Molecule; ULIP-6; DRP-5; Collapsin Response Mediator Protein-5; Dihydropyrimidinase-Like 5; RTSC4; ULIP6
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human DPYSL5 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1 kappa
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    25H4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:2500-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May have a function in neuronal differentiation and/or axon growth.
  • 基因功能參考文獻：
    1. Study describes the relevance of DRP5 during osteosarcoma development. DRP5 was upregulated in osteosarcoma specimens and cell lines and shown to function via the downstream MMPs. Inhibition of DRP5 suppressed the growth of cancer cells in vitro and in vivo, and high expression levels of DRP5 were associated with poor prognosis in osteosarcoma patients. PMID: 28374915
    2. Our findings suggest that CRMP5 serves as a major mediator of Notch signaling and Akt activation by controlling the degradation of the Notch receptor, with implications for defining a biomarker signature in glioblastoma PMID: 26122847
    3. present study suggested that CRAM could be a clinical prognostic marker for patients with cervical cancer PMID: 24695578
    4. study elucidates a novel regulatory mechanism that utilizes CRMP5-induced mitophagy to orchestrate proper dendrite outgrowth and neuronal function. PMID: 24324268
    5. identified residues that are crucial for determining the preference for hetero-oligomer or homo-oligomer formation. In spite of being the CRMP family member most closely related to dihydropyrimidinase, CRMP-5 does not have amidohydrolase activity. PMID: 23373749
    6. New CRMP5 isoform present in the nucleus is associated with Glioma. PMID: 23298946
    7. CRMP-5-IgG defines a paraneoplastic ophthalmological entity of combined optic neuritis and retinitis with vitreous inflammatory cells. PMID: 12838519
    8. CRMP-5 autoimmune myelopathy and occult neoplasia are important considerations in patients with insidiously progressive myelopathy, especially with known cancer risk. PMID: 18306241
    9. We describe a patient with optic neuropathy and vitritis as the only clinical manifestations of paraneoplastic optic neuropathy secondary to lung cancer marked by an extremely high titer of CRMP-5 antibody. PMID: 18347453
    10. findings point at CRMP5 as a novel marker for distinguishing between highly aggressive neuroendocrine carcinoma and the other lung cancers. PMID: 18769332
    11. patients with CV2/CRMP5-Ab and thymoma developed myasthenic syndrome more frequently PMID: 18931014

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Metallo-dependent hydrolases superfamily, Hydantoinase/dihydropyrimidinase family
  • 數據庫鏈接：

    HGNC: 20637

    OMIM: 608383

    KEGG: hsa:56896

    STRING: 9606.ENSP00000288699

    UniGene: Hs.299315