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DPP8 Monoclonal Antibody

  • 中文名稱：
    DPP8 Monoclonal Antibody
  • 貨號：
    CSB-MA915152
  • 規格：
    ￥1320
  • 圖片：
    • Western blotting analysis using dipeptidyl peptidase 8 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with dipeptidyl peptidase 8 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) DPP8 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    DPP8
  • 別名：
    DPP8; Dipeptidyl Peptidase 8; DPRP1; DP8; Dipeptidyl Peptidase VIII; Prolyl Dipeptidase DPP8; MSTP141; Dipeptidyl Peptidase IV-Related Protein 1; FLJ14920; FLJ20283; MGC26191; DPP VIII; DPRP-1; Dipeptidyl Peptidase IV-Related Protein-1; Dipeptidyl-Peptidase 8; Dipeptidylpeptidase 8; EC 3.4.14.5; MSTP097; MSTP135; MST097
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human DPP8 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    12D1
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:400-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (Probable). Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism.
  • 基因功能參考文獻：
    1. The DPP8 expressing cell model system is a very useful and promising system for investigating the selectivity and associated toxicity of DPP4 inhibitors on DPP8. PMID: 25464020
    2. The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9. PMID: 24072711
    3. Suggest roles for DPP8 and DPP9 in lymphocyte activation and apoptosis and in hepatocytes during liver disease pathogenesis. PMID: 23704821
    4. DPP8 was found in macrophages of carotid atherosclerotic plaque and may play a role in disease progression. PMID: 23608773
    5. analysis of dipeptidyl peptidases 8 and 9 reveals that they may have compensatory roles PMID: 23519473
    6. this study demonstrates for the first time that DP8 and DP9 are expressed in breast and ovarian carcinoma cell lines PMID: 22736146
    7. Data identify modification points in the topology of a representative DPP8/9-inhibitor, capable of rendering selectivity for DPP8 over DPP9. PMID: 21711053
    8. This is the first study to demonstrate the presence of DP8 in chronic lymphocytic leukemia (CLL) and the upregulation of DP8 mRNA in CLL. PMID: 20534982
    9. DPP8 and DPP9 prevail over canonical DPP-IV/CD26 and FAPalpha in all examined meningioma patients PMID: 20043068
    10. cells overexpressing DP8 exhibit behavioral changesin the presence of ECM components; these effects were independent of enzyme activity PMID: 16700509
    11. Dipeptidyl peptidase 8 and dipeptidyl peptidase 9 influence cell-extracellular matrix interactions, and thus may regulate tissue remodeling. PMID: 16704418
    12. study has identified the residues absolutely required for the optimal activity of DPP8 and its unique substrate specificity PMID: 17040910
    13. DP8 cleavage of the N-terminal two residues of IP10 (CXCL10), ITAC (CXCL11) and SDF-1 (CXCL12), is reported. PMID: 18275857
    14. DP8 and DP9 tissue and cellular expression PMID: 19581630

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase S9B family, DPPIV subfamily
  • 組織特異性：
    Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain.
  • 數據庫鏈接：

    HGNC: 16490

    OMIM: 606819

    KEGG: hsa:54878

    STRING: 9606.ENSP00000339208

    UniGene: Hs.458609