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DENR Monoclonal Antibody

  • 中文名稱：
    DENR Monoclonal Antibody
  • 貨號(hào)：
    CSB-MA547376
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western blotting analysis using DENR antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with DENR antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Mouse anti-Homo sapiens (Human) DENR Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    DENR
  • 別名：
    DENR; Density Regulated Re-Initiation And Release Factor; SMAP-3; DRP1; DRP; Density-Regulated Protein; Smooth Muscle Cell Associated Protein-3; Smooth Muscle Cell-Associated Protein 3; Protein DRP1
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human DENR protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG2b
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    4E5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.
  • 基因功能參考文獻(xiàn)：
    1. findings elucidate how the DENR-MCT-1 dimer interacts with the ribosome and have functional implications for the mechanism of unconventional translation initiation and reinitiation. PMID: 28723557
    2. DENR binds to the P-site of the 40S ribosomal subunit and together with MCTS1 forms a tRNA binding surface and interfere with eIF1/eIF2/eIF3 binding, thus operating in ribosome recycling and translation re-initiation PMID: 28723557
    3. Reinitiation complexes involving initiation factors eIF2D, MCT-1, and DENR controls the translation of a large fraction of mammalian cellular mRNAs. PMID: 28732596
    4. both HuR and AUF1 bind to discrete regions of DENR/DRP mRNA and that AUF1 silencing increases DENR/DRP protein levels. PMID: 17878526
  • 蛋白家族：
    DENR family
  • 組織特異性：
    Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 2769

    OMIM: 604550

    KEGG: hsa:8562

    STRING: 9606.ENSP00000280557

    UniGene: Hs.22393