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  4. DEF6 Monoclonal Antibody

DEF6 Monoclonal Antibody

  • 中文名稱：
    DEF6 Monoclonal Antibody
  • 貨號：
    CSB-MA778713
  • 規格：
    ￥1320
  • 圖片：
    • Immunocytochemical staining of Jurkat cells with DEF6 antibody. Nuclei were stained blue with DAPI; DEF6 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Flow cytometric analysis of DEF6 expression in Jurkat cells using DEF6 antibody. Green, isotype control; red, DEF6.
    • Western blotting analysis using DEF6 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with DEF6 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) DEF6 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    DEF6
  • 別名：
    DEF6; DEF6 Guanine Nucleotide Exchange Factor; IBP; SWAP70L; SLAT; Differentially Expressed In FDCP 6 Homolog; SWAP-70-Like Adaptor Protein Of T Cells; IRF4-Binding Protein; DEF-6; Differentially Expressed In FDCP (Mouse Homolog) 6; Differentially Expressed In FDCP 6 Homolog (Mouse); IMD87
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human DEF6 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    19B9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:2500
    FC 1:100-1:1000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling.
  • 基因功能參考文獻：
    1. this study identifies Def6 as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions PMID: 28314855
    2. DEF6 expression may serve as an independent prognostic factor, and interacted positively with p16 toward high tumor stage and shorter survival. PMID: 27488395
    3. IBP was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases PMID: 23088770
    4. DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies. PMID: 22829599
    5. Molecular cloning of IBP, a guanine nucleotide exchange factor, which is highly expressed in the immune system. PMID: 12651066
    6. IBP is a novel guanine nucleotide exchange factor and is recruited to the immunological synapse by T cell receptor engagement PMID: 12923183
    7. DEF6 not only activates Rho-family GTPases but also cooperates with activated Rac1 to exert its cellular function PMID: 17121847
    8. level of expression correlates with the degree of malignancy in breast carcinoma tissues PMID: 19393345
    9. Overexpression of the Interferon regulatory factor 4-binding protein is associated with Colorectal Carcinoma. PMID: 19679060
    10. DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA. PMID: 15023524

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  • 亞細胞定位：
    Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, filopodium.
  • 組織特異性：
    Broadly expressed in the immune system and can be detected in T and B-cells.
  • 數據庫鏈接：

    HGNC: 2760

    OMIM: 610094

    KEGG: hsa:50619

    STRING: 9606.ENSP00000319831

    UniGene: Hs.15476