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CMPK1 Monoclonal Antibody

  • 中文名稱：
    CMPK1 Monoclonal Antibody
  • 貨號：
    CSB-MA252376
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of CMPK1 expression in HepG2 cells using CMPK1 antibody. Green, isotype control; red, CMPK1.
    • Immunocytochemical staining of HepG2 cells with CMPK1 antibody. Nuclei were stained blue with DAPI; CMPK1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain:. Scale bar, 20 μm.
    • Western blotting analysis using CMPK1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with CMPK1 antibody and HRP-conjugated goat mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) CMPK1 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CMPK1; Cytidine/Uridine Monophosphate Kinase 1; UMP-CMP Kinase; UMP/CMP Kinase; UMP-CMPK; CMPK; Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic; Uridine Monophosphate/Cytidine Monophosphate Kinase; Nucleoside-Diphosphate Kinase; Deoxycytidylate Kinase; Cytidylate Kinase; DCMP Kinase; EC 2.7.4.14; UMPK; CMK; UMK; CK; Cytidine Monophosphate Kinase; Uridine Monophosphate Kinase; EC 2.7.4.6; UMP/CMPK; EC 2.7.4; UCK
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human CMPK1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    17G2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
    FC 1:100-1:1000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
  • 基因功能參考文獻：
    1. Nuclear CMPK1 expression is indicative of poor prognosis in the triple negative breast cancer patients. PMID: 27558661
    2. TGF-b1 inhibited the expression of CMPK, which was blocked in the presence of a TGF-b type I receptor, SB431542, and was abolished by the inhibitor of miR-130b-3p, indicating that CMPK is regulated by the TGF-b signalling pathway through the upregulation of miR-130b-3p. PMID: 28414100
    3. The role of CMP/UMP kinase (CMPK), an enzyme catalyzes cytidine diphosphate formation, in DNA repair, was investigated. PMID: 25659034
    4. CMPK1 and RBP3 are associated with corneal curvature in Asian populations. PMID: 24963161
    5. In particular, polymorphisms of the CMPK1 gene seem to provide important prognostic information PMID: 22838950
    6. Single-nucleotide polymorphisms in CMPK1 gene is associated with treatment response in non-small cell lung cancer. PMID: 21642870
    7. UMP/CMP kinase (EC 2.7.4.14) is not critical for the phosphorylation of CMP, dCMP and maintenance of natural nucleotide pools in cells PMID: 21559290
    8. thymidylate synthase/ribonucleotide reductase gene silencing and deoxycytidine kinase::uridine monophosphate kinase fusion gene gene overexpression markedly improved gemcitabine's therapeutic activity PMID: 19568409
    9. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. PMID: 11912132
    10. UMP/CMP kinase reveals the conformational changes that occur upon substrate binding PMID: 15163660
    11. Models for the phosphorylation action and substrate specificity of human UMP/CMP kinase. PMID: 15550676
    12. Several uracil vinylphosphonate derivatives had affinities for human UMP-CMP kinase similar to those of dUMP PMID: 17608725

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  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Adenylate kinase family, UMP-CMP kinase subfamily
  • 組織特異性：
    Ubiquitously expressed.
  • 數據庫鏈接：

    HGNC: 18170

    OMIM: 191710

    KEGG: hsa:51727

    STRING: 9606.ENSP00000360939

    UniGene: Hs.731647