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CISD2 Monoclonal Antibody

  • 中文名稱：
    CISD2 Monoclonal Antibody
  • 貨號：
    CSB-MA017455
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Immunocytochemical staining of C2C12 cells with CDGSH iron sulfur domain 2 antibody. Nuclei were stained blue with DAPI; CDGSH iron sulfur domain 2 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 μm.
    • Western blotting analysis using CDGSH iron sulfur domain 2 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with CDGSH iron sulfur domain 2 antibody and HRP-conjugated goat mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) CISD2 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    CISD2
  • 別名：
    CISD2; CDGSH Iron Sulfur Domain 2; Miner1; NAF-1; ERIS; Endoplasmic Reticulum Intermembrane Small Protein; Nutrient-Deprivation Autophagy Factor-1; ZCD2; CDGSH Iron-Sulfur Domain-Containing Protein 2; Zinc Finger, CDGSH-Type Domain 2; MitoNEET-Related 1 Protein; WFS2; MitoNEET Related 1; Wolfram Syndrome 2; CDGSH2
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human CISD2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    18H7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
  • 基因功能參考文獻：
    1. CDGSH iron-sulfur domain-containing protein 2 (CISD2) Wolfram syndrome type 2 (WFS2) primary fibroblast cell lines showed consistent reduction in proliferation. PMID: 29239282
    2. CISD2 haploinsufficiency disrupts calcium homeostasis, causing ER stress and subsequent nonalcoholic fatty liver disease and nonalcoholic steatohepatitis PMID: 29166610
    3. CISD2 was increased in glioma samples and was associated with poor prognosis and aggressive tumor behavior. The miR449a/CISD2/beclin1mediated autophagy regulatory network contributed to the proliferation of glioma cells PMID: 28983596
    4. CISD2 is down-regulated in gastric cancer, and its effects on the inhibition of cellular proliferation, metastatic ability, and increased chemotherapy sensitivity are mediated by antagonism to 5-FU-induced autophagy through the AKT/mTOR pathway. PMID: 28857517
    5. The c.103 + 1G > A mutation resulted in the loss of functional CISD2 protein in the two Italian Wolfram syndrome type 2 patients. PMID: 29237418
    6. CISD2 was up-regulated in laryngeal squamous cell carcinoma PMID: 27007153
    7. CISD2 could be an independent prognostic factor for PC and suggested that the CISD2/Wnt/beta-catenin pathway contributed to the proliferation of PC and EMT PMID: 27983920
    8. the patient that we describe in this report with the c.215A > G missense CISD2 variant had the classical features of Wolfram syndrome type 1. The c.215A > G (p.Asn72Ser) variant does not induce CISD2 RNA mis-splicing or a reduction in CISD2 protein levels. Thus, we report a novel missense homozygous CISD2 mutation in a patient with clinical features that differ from previously reported Wolfram syndrome 2 case reports. PMID: 28335035
    9. CISD2 exerts anti-apoptotic and anti-inflammatory effects in neural cells; and (2) curcumin can attenuate the downregulation of CISD2 in SCI and LPS-treated astrocytes. PMID: 26387034
    10. CISD2 protein may serve as a candidate prognostic marker and a novel therapeutic target for hepatocellular carcinoma (HCC) and play an important role in promoting proliferation and enhanced progression of HCC. PMID: 26722601
    11. The findings suggested that CISD2 haplotype-tagging single nucleotide polymorphisms are not associated with Alzheimer's disease risk. PMID: 26154755
    12. NAF-1 is a BCL-2-associated co-factor that targets BCL-2 for antagonism of the autophagy pathway at the endoplasmic reticulum. PMID: 20010695
    13. NAF-1 as a previously unidentified cell target of anti-diabetes thiazolidinedione drugs. PMID: 23717386
    14. provides the first structural information, to our knowledge, for future targeting of the NAF-1-Bcl-2 complex in the regulation of apoptosis/autophagy in cancer biology PMID: 24706857
    15. High CISD2 expression was significantly associated with gastric cancer. PMID: 26565812
    16. NAF-1 is a major player in the metabolic regulation of breast cancer cells. PMID: 26621032
    17. A novel CISD2 mutation is associated with wolfram syndrome 2. PMID: 25371195
    18. Studied the expression pattern and clinicopathological significance of CISD2 in patients with early-stage cervical cancer. PMID: 25134919
    19. Data show that the protein levels of NAF-1 (CISD2) and mNT (CISD1) are elevated in human epithelial breast cancer cells. PMID: 23959881
    20. CISD2 has a role in lifespan control and disease [review] PMID: 20649540
    21. Novel mutation, new phenotypic variant with no diabetes insipidus, presence of peptic ulcer disease, platelet aggregation defect PMID: 14724730
    22. A single missense mutation was identified in a novel, highly conserved zinc-finger gene, ZCD2, in three consanguineous families of Jordanian descent with Wolfram syndrome (WFS). PMID: 17846994
    23. The authors show that Miner1 is a homodimer harboring two redox-active 2Fe-2S clusters, indicating for the first time an association of a redox-active FeS protein with Wolfram Syndrome 2. PMID: 19580816

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  • 相關疾病：
    Wolfram syndrome 2 (WFS2)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. Note=According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane.
  • 蛋白家族：
    CISD protein family, CISD2 subfamily
  • 組織特異性：
    Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24212

    OMIM: 604928

    KEGG: hsa:493856

    STRING: 9606.ENSP00000273986

    UniGene: Hs.444955