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CINP Monoclonal Antibody

  • 中文名稱：
    CINP Monoclonal Antibody
  • 貨號：
    CSB-MA246369
  • 規格：
    ￥1320
  • 圖片：
    • Western blotting analysis using CINP antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with CINP antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) CINP Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    CINP
  • 別名：
    CINP; Cyclin Dependent Kinase 2 Interacting Protein; Cyclin-Dependent Kinase 2-Interacting Protein; CDK2-Interacting Protein; MGC849
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human CINP protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG2b
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    18F12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.
  • 基因功能參考文獻：
    1. NS5B delays cells in S phase through interaction with CINP and relocalization of the protein from the nucleus to the cytoplasm PMID: 21628470
    2. CINP is part of the Cdc7-dependent mechanism of origin firing and a functional and physical link between Cdk2 and Cdc7 complexes at the origins PMID: 16082200
    3. CINP interacts with ATR-interacting protein and regulates ATR-dependent signaling, resistance to replication stress, and G2 checkpoint integrity. PMID: 19889979
  • 亞細胞定位：
    Nucleus. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.
  • 蛋白家族：
    CINP family
  • 數據庫鏈接：

    HGNC: 23789

    OMIM: 613362

    KEGG: hsa:51550

    STRING: 9606.ENSP00000442057

    UniGene: Hs.129634