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  4. CBX8 Monoclonal Antibody

CBX8 Monoclonal Antibody

  • 中文名稱：
    CBX8 Monoclonal Antibody
  • 貨號：
    CSB-MA283572
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Chromobox 8 expression in HeLa cells using Chromobox 8 antibody. Green, isotype control; red, Chromobox 8.
    • Western blotting analysis using chromobox 8 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with chromobox 8 antibody and HRP-conjugated goat mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) CBX8 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    CBX8
  • 別名：
    CBX8; Chromobox 8; RC1; PC3; Chromobox Protein Homolog 8; Rectachrome 1; Polycomb 3; HPC3; Chromobox Homolog 8 (Pc Class Homolog, Drosophila); Chromobox Homolog 8 (Drosophila Pc Class); Pc Class 3 Homolog (Drosophila); Chromobox Homolog 8; Pc Class 3 Homolog; Polycomb 3 Homolog; HPc3; Pc3
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human CBX8 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG2b
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    19G4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
    FC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
  • 基因功能參考文獻：
    1. CBX8 functions as an oncogene to upregulate EGR1 and miR-365-3p to stimulate the AKT/beta-catenin pathway in hepatocellular carcinoma.CBX8 expression is increased and associated with poor outcomes in hepatocellular carcinoma. PMID: 29066512
    2. CBX8 binds with the Snai1 promoter, represses Snai1 transcription and suppresses esophageal carcinoma metastasis. PMID: 28912889
    3. The data suggest that high expression of CBX8 plays a critical oncogenic role in aggressiveness of urothelial carcinoma cells of the bladder through promoting cancer cell proliferation by repressing the p53 pathway, and CBX8 could be used as a novel predictor for muscle invasive bladder cancer patients. PMID: 28837252
    4. CBX8 binds to H3K27me3 at bivalent promoters during germinal center formation, and recruits a novel PRC1-BCOR complex at BCL6 binding sites to specifically silence genes in the germinal center and promote lymphomagenesis PMID: 27505670
    5. CBX8 plates roles in epigenetic regulation in DNA damage response. PMID: 27555324
    6. IGF1 can promote the colon cancer cell line, HCT116 cell, proliferation via promoting Cbx8 expression PMID: 25398592
    7. The difference in the SUZ12 and CBX8 genes expression were significantly divergent between tumors and their marginal tissues. PMID: 26837964
    8. These data suggest that CBX8 modulates SIPS through the RB-E2F1 pathway in CML cells and provide important insight into its application in CML treatment. PMID: 26718407
    9. Low CBX8 expression was associated with distant metastasis in colorectal cancer. PMID: 25360999
    10. CBX8 might emerge as an oncogene for promoting the proliferation of tumor cells and raising the resistance of neoplasms to chemotherapy. PMID: 25197352
    11. The presence of CBX8-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics. PMID: 24460908
    12. Interaction with CBX8 precludes AF9-DOT1L binding. PMID: 23891621
    13. CBX8 cooperated with SIRT1 for suppressing p53 acetylation induced by Sirtinol and etoposide/TSA. Upon ectopic expression, CBX8 or SIRT1 repressed the expression of p21(WAF1) by inhibiting p53 binding to the promoter. PMID: 23474493
    14. CBX8 plays an essential role in MLL-AF9 transcriptional regulation and leukemogenesis. PMID: 22094252
    15. CBX8 is an essential component of one of the polycomb repressive complexes, which directly regulate the expression of numerous target genes, including the INK4A-ARF locus, involved in cell-fate decisions. PMID: 17332741

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  • 亞細胞定位：
    Nucleus.
  • 數據庫鏈接：

    HGNC: 15962

    OMIM: 617354

    KEGG: hsa:57332

    STRING: 9606.ENSP00000269385

    UniGene: Hs.387258