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CAMLG Monoclonal Antibody

  • 中文名稱：
    CAMLG Monoclonal Antibody
  • 貨號：
    CSB-MA043475
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Calcium modulating ligand expression in HeLa cells using Calcium modulating ligand antibody. Green, isotype control; red, Calcium modulating ligand.
    • Western blotting analysis using calcium modulating ligand antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with calcium modulating ligand antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) CAMLG Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    CAMLG
  • 別名：
    CAMLG; Calcium Modulating Ligand; CAML; GET2; Guided Entry Of Tail-Anchored Proteins Factor CAMLG; Calcium Signal-Modulating Cyclophilin Ligand; Calcium-Modulating Cyclophilin Ligand; Cyclophilin B-Binding Protein; Calcium-Signal Modulating Cyclophilin Ligand; CDG2Z
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human CAMLG protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    2C11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
    FC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.
  • 基因功能參考文獻：
    1. Found that the calcium-modulating cyclophilin ligand (CAMLG), which is involved in Ca(2+) signaling, was the major host cell PilA binding protein. PMID: 23266901
    2. Results indicate calcium-modulating cyclophilin ligand (CAML) and WRB as components of the TRC40 receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells. PMID: 23041287
    3. CAML was found to play a crucial role in the PRL/PRLR-dependent growth of breast cancer cells. PMID: 21128111
    4. this study demonstrated that DENV manipulated the levels of CAML to subvert the apoptotic process which in turn favoured efficient virus production. PMID: 22281498
    5. CAMLG was more frequently significantly overexpressed in acute myeloid leukemia patients with CD56 immunophenoytpe PMID: 12031912
    6. Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets cellular CAML to increase the cytosolic Ca(2+) response, which consequently protects cells from mitochondrial damage and apoptosis PMID: 12388711
    7. CAML is an important signal transducer for the actions of Ang II in regulating the calcineurin-NFAT pathway and the interaction of CAML with ATRAP may mediate the Ang II actions in vascular physiology PMID: 15668245
    8. The intracellular C-terminus of fibrocystin interacts with CAML, a protein with an intracellular distribution that is similar to that of PKD2. PMID: 16243292
    9. Binding of the MUC1 CT to CAML in human epithelial cells was confirmed by reciprocal coimmunoprecipitations, confocal microscopy, protein crosslinking, and coupled transcription/translation analyses. PMID: 19135167

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  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 組織特異性：
    Ubiquitous. Highest levels in brain, testis and ovary.
  • 數據庫鏈接：

    HGNC: 1471

    OMIM: 601118

    KEGG: hsa:819

    STRING: 9606.ENSP00000297156

    UniGene: Hs.529846