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BDH2 Monoclonal Antibody

  • 中文名稱：
    BDH2 Monoclonal Antibody
  • 貨號：
    CSB-MA921248
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of 3-hydroxybutyrate dehydrogenase 2 expression in HepG2 cells using 3-hydroxybutyrate dehydrogenase 2 antibody. Green, isotype control; red, 3-hydroxybutyrate dehydrogenase 2.
    • Western blotting analysis using 3-hydroxybutyrate dehydrogenase 2 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with 3-hydroxybutyrate dehydrogenase 2 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) BDH2 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    BDH2
  • 別名：
    BDH2; 3-Hydroxybutyrate Dehydrogenase 2; SDR15C1; PRO20933; UCPA-OR; UNQ6308; DHRS6; Short Chain Dehydrogenase/Reductase Family 15C Member 1; Dehydrogenase/Reductase SDR Family Member 6; 3-Hydroxybutyrate Dehydrogenase, Type 2; (R)-Beta-Hydroxybutyrate Dehydrogenase; 4-Oxo-L-Proline Reductase; Oxidoreductase UCPA; FLJ13261; Short Chain Dehydrogenase/Reductase Family 15C, Member 1; Dehydrogenase/Reductase (SDR Family) Member 6; 3-Hydroxybutyrate Dehydrogenase Type 2; R-Beta-Hydroxybutyrate Dehydrogenase; EC 1.1.1.104; EC 1.1.1.30; EC 1.1.1.-; EFA6R
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human BDH2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG2a
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    17F2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
    FC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria. Also acts as a 3-hydroxybutyrate dehydrogenase.
  • 基因功能參考文獻：
    1. High expression level of BDH2 is associated with esophageal squamous cell carcinoma. PMID: 26799587
    2. intracellular expression in macrophages is downregulated by stress and inflammation PMID: 25762501
    3. BDH2 expression is an independent poor prognostic factor for CN-AML, with an anti-apoptotic role. Patients with high BDH2 expression have relatively shorter overall survival and a low complete response rate. PMID: 23941109
    4. Iron-mediated post-transcriptional regulation of hBDH2 controls mitochondrial iron homeostasis in human cells. PMID: 22527885
    5. Data show that the ketone body metabolizing enzymes BDH1, BDH2, OXCT1 and ACAT1 were expressed at the mRNA and protein level in all glioma cell lines. PMID: 21791085
    6. DHRS6 is an orphan short chain dehydrogenase/ reductase enzyme PMID: 16380372

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 組織特異性：
    Detected in liver (at protein level).
  • 數據庫鏈接：

    HGNC: 32389

    KEGG: hsa:56898

    STRING: 9606.ENSP00000296424

    UniGene: Hs.124696