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ATIC Monoclonal Antibody

  • 中文名稱：
    ATIC Monoclonal Antibody
  • 貨號：
    CSB-MA253242
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of ATIC expression in C2C12 cells using ATIC antibody. Green, isotype control; red, ATIC.
    • Western blotting analysis using ATIC antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with ATIC antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) ATIC Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    ATIC
  • 別名：
    ATIC; 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase; PURH; IMPCHASE; AICARFT; Phosphoribosylaminoimidazolecarboxamide Formyltransferase/IMP Cyclohydrolase; AICAR Transformylase/Inosine Monophosphate Cyclohydrolase; Bifunctional Purine Biosynthesis Protein ATIC; 5-Aminoimidazole-4-Carboxamide-1-Beta-D-Ribonucleotide Transformylase/Inosinicase; AICAR Formyltransferase/IMP Cyclohydrolase Bifunctional Enzyme; Epididymis Secretory Sperm Binding Protein Li 70p; Bifunctional Purine Biosynthesis Protein PURH; AICARFT/IMPCHASE; HEL-S-70p; AICAR
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human ATIC protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    4G10
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:400-1:2000
    FC 1:200-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization.
  • 基因功能參考文獻：
    1. ATIC acts as an oncogenic gene that promotes survival, proliferation and migration by targeting AMPK-mTOR-S6 K1 signaling PMID: 29246230
    2. The AICARFT site is capable of independently binding both nucleotide and folate substrates with high affinity however no evidence for positive cooperativity in binding could be detected using the model ligands employed in this study. PMID: 29042184
    3. Pediatric Osteosarcoma patients with ATIC 347C>G exhibited a good histologic response to chemotherapy PMID: 28267080
    4. The ATIC 347 C/G polymorphism may be associated with non-responsiveness to and or toxicity of methotrexate in Caucasian rheumatoid arthritis patients. PMID: 27379764
    5. ATIC 347C>G gene polymorphism may be associated with the development of MTX induced gastrointestinal adverse events. PMID: 26799664
    6. genotyping of ATIC rs2372536 and ITPA rs1127354 variants or measuring ITPA activity could be useful to predict methotrexate response in children with juvenile idiopathic arthritis. PMID: 25240429
    7. This study shows that polymorphisms on genes related to the metabolic pathway of pemetrexed, especially, ATIC and GGH genes, would have a therapeutic implication in pemetrexed-treated patients with lung adenocarcinoma PMID: 25823786
    8. PTPLAD1 and AMPK are rapidly compartmentalized within the plasma membrane (PM) and Golgi/endosome fractions after insulin stimulation and that ATIC later accumulates in the Golgi/endosome fraction. PMID: 25687571
    9. Single nucleotide polymorphisms in ATIC gene is associated with acute graft-versus-host disease. PMID: 25425682
    10. Our data show that ATIC is in complex with insulin receptor (IR)and siRNA-mediated partial knockdown of ATIC in HEK293 cells, decreases IR tyrosine phosphorylation and regulates IR endocytosis. Insulin stimulation and ATIC knockdown readily increase level of AMPK-Thr172 phosphorylation in IR complexes.ATIC depletion delayed insulin response of Glut2 translocation in HEK293 cells and decreased AKT-Ser473 phosphorylation. PMID: 25687571
    11. MTHFR, DHFR and ATIC genetic variants can be considered as pharmacogenetic markers of outcome in RA patients under MTX monotherapy. PMID: 25084201
    12. study suggests that MTHFR C677T and ATIC T675C genotyping combined with clinicopathological data may help to identify patients whom will not benefit from MTX treatment and, therefore, assist clinicians in personalizing RA treatment PMID: 24967362
    13. Results proved in cultured skin fibroblasts from patients with AICA-ribosiduria that various mutations of ATIC destabilize to various degrees purinosome assembly. PMID: 22180458
    14. The kinetic mechanism of the human bifunctional enzyme ATIC PMID: 11948179
    15. crystal structure of ATIC PMID: 14966129
    16. Deficiency in AICAR transformylase is associated with severe neurological defects and congenital blindness PMID: 15114530
    17. Polymorphisms of reduced folate carrier,aminoimidazole carboxamide ribonucleotide transformylase,and thymidylate synthase genes contribute to the therapeutic response in rheumatoid arthritis patients to methotrexate. PMID: 15457444
    18. AS160 is a common target of insulin, IGF-1, EGF, PMA and AICAR, these stimuli induce distinctive patterns of phosphorylation and 14-3-3 binding, mediated by at least four protein kinases. PMID: 17617058

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  • 相關疾病：
    AICAR transformylase/IMP cyclohydrolase deficiency (AICAR)
  • 蛋白家族：
    PurH family
  • 組織特異性：
    Present in the heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas.
  • 數據庫鏈接：

    HGNC: 794

    OMIM: 601731

    KEGG: hsa:471

    STRING: 9606.ENSP00000236959

    UniGene: Hs.90280