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ASCC2 Monoclonal Antibody

  • 中文名稱：
    ASCC2 Monoclonal Antibody
  • 貨號：
    CSB-MA588780
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of ASCC2 expression in HepG2 cells using ASCC2 antibody. Green, isotype control; red, ASCC2.
    • Immunocytochemical staining of HepG2 cells with ASCC2 antibody. Nuclei were stained blue with DAPI; ASCC2 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and Smart Gain: Low. Scale bar, 20 μm.
    • Western blotting analysis using ASCC2 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with ASCC2 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) ASCC2 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    ASCC2
  • 別名：
    ASCC2; Activating Signal Cointegrator 1 Complex Subunit 2; ASC1p100; ASC-1 Complex Subunit P100; Trip4 Complex Subunit P100; DKFZp586O0223; FLJ21588; ASC 1 Complex Subunit P100; ASC1P100; P100; RQT3
  • 宿主：
    Mouse
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human ASCC2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    13C12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:200-1:1000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. As part of the ribosome quality control trigger (RQT) complex, recognizes ZNF598-dependent ubiquitination of stalled ribosomes.
  • 亞細胞定位：
    Nucleus. Nucleus speckle.
  • 蛋白家族：
    ASCC2 family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 24103

    OMIM: 614216

    KEGG: hsa:84164

    STRING: 9606.ENSP00000305502

    UniGene: Hs.731754