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ARCN1 Monoclonal Antibody

  • 中文名稱(chēng)：
    ARCN1 Monoclonal Antibody
  • 貨號(hào)：
    CSB-MA271413
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western blotting analysis using archain 1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with archain 1 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Mouse anti-Homo sapiens (Human) ARCN1 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    ARCN1
  • 別名：
    ARCN1; Archain 1; COPD; Coatomer Protein Complex, Subunit Delta; COPI Coat Complex Subunit Delta; Coatomer Subunit Delta; Delta-Coat Protein; Delta-COP; Archain Vesicle Transport Protein 1; Coatomer Protein Delta-COP; Coatomer Delta Subunit; Archain; SRMMD; SSMG
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human ARCN1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    24B7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
  • 基因功能參考文獻(xiàn)：
    1. report of a clinically recognizable craniofacial disorder characterized by facial dysmorphisms, severe micrognathia, rhizomelic shortening, microcephalic dwarfism, and mild developmental delay due to loss-of-function heterozygous mutations in ARCN1, which encodes the coatomer subunit delta of COPI PMID: 27476655
    2. The authors demonstrated that miR-33a could impede influenza A virus replication at the stage of virus internalization by suppressing ARCN1 expression. PMID: 26498766
    3. Single nucleotide polymorphisms in the PHLDB1 and ARCN1 genes are associated with increased risk of Glioma. PMID: 23300798
    4. native crystals of delta-COP had unit-cell parameters a = 100.23, b = 136.77, c = 44.39 A PMID: 22750876
  • 相關(guān)疾病：
    Short stature, rhizomelic, with microcephaly, micrognathia, and developmental delay (SRMMD)
  • 亞細(xì)胞定位：
    Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Adaptor complexes medium subunit family, Delta-COP subfamily
  • 組織特異性：
    Ubiquitously expressed.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 649

    OMIM: 600820

    KEGG: hsa:372

    STRING: 9606.ENSP00000264028

    UniGene: Hs.33642