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  4. Recombinant Horse Interleukin-1 Receptor Antagonist protein (IL1RN)

Recombinant Horse Interleukin-1 Receptor Antagonist protein (IL1RN)

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  • 中文名稱：
    Recombinant Horse Interleukin-1 Receptor Antagonist protein(IL1RN) (Active)
  • 品名簡稱：
    Recombinant Horse IL1RN protein (Active)
  • 貨號：
    CSB-AP003491HO
  • 說明書：
  • 規格：
    ￥852
  • 圖片：
  • 其他：

產品詳情

  • 純度：
    >95% as determined by SDS-PAGE.
  • 內毒素：
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性：
    Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1α- dependent proliferation of murine D10S cells is less than 3.0 μg/ml, corresponding to a specific activity of >333 IU/mg in the presence of 50 pg/ml rHuIL-1α.
  • 基因名：
    IL1RN
  • Uniprot No.：
  • 別名：
    IL1RN; IL1RAInterleukin-1 receptor antagonist protein; IL-1RN; IL-1ra; IRAP; IL1 inhibitor
  • 種屬：
    Equus caballus (Horse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.Coli
  • 分子量：
    17.4 kDa
  • 表達區域：
    26-177aa
  • 氨基酸序列
    HPLGKRPCKM QAFRIWDVNQ KTFYMRNNQL VAGYLQESNT KLQEKIDVVP IEPDALFLGL HGRKLCLACV KSGDEIRFQL EAVNITDLSK NKEENKRFTF IRSNSGPTTS FESAACPGWF LCTAQEADRP VSLTNKPKES FMVTKFYLQE DQ
  • 蛋白標簽：
    Tag-Free
  • 產品提供形式：
    Liquid or Lyophilized powder
  • 緩沖液：
    0.2 μm filtered PBS, pH 7.4 ,lyophilized
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    5-10 business days
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
  • 基因功能參考文獻：
    1. This is the first study in an equine model to establish a dosing/redosing protocol, as well as examine the Nab response to capsid and supports further clinical investigation to determine the clinical efficacy of scAAVIL-1ra to treat osteoarthritis. PMID: 25902762
    2. Expression of IL-1RN in the endometrium is likely regulated by estradiol and progesterone and suggest that IL-1RN regulates the degree of IL-1 signal transduction and thereby plays an important role in the establishment of equine pregnancy. PMID: 19157767
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    IL-1 family
  • 數據庫鏈接：