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  4. Rat Haptoglobin,Hpt/HP ELISA KIT

Rat Haptoglobin,Hpt/HP ELISA KIT

  • 中文名稱：
    大鼠結(jié)合珠蛋白/觸珠蛋白(Hpt/HP)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E08587r
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3900/￥2500
  • 促銷：
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠結(jié)合珠蛋白/觸珠蛋白(Hpt/HP)酶聯(lián)免疫試劑盒（CSB-E08587r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養(yǎng)上清液、組織勻漿,支氣管肺泡灌洗液、尿液樣本中的HP含量。試劑盒檢測范圍為0.156 μg/mL-10 μg/mL，適用于科研領(lǐng)域研究肝臟疾病、溶血性貧血、炎癥反應(yīng)或感染性疾病模型中Hpt/HP的動態(tài)變化，也可用于評估實驗干預(yù)（如藥物處理或基因修飾）對大鼠Hpt/HP表達調(diào)控的影響。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Hp ELISA Kit; Ba1-647 ELISA Kit; Haptoglobin ELISA Kit; Liver regeneration-related protein LRRG173) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain] ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, cell culture supernates, tissue homogenates,bronchoalveolar lavage fluid, urine
  • 檢測范圍：
    0.156 μg/mL-10 μg/mL
  • 靈敏度：
    0.039 μg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
  • 基因功能參考文獻：
    1. This study demonistrated that increased Hp in serum came from the liver in response to TBI and that IL-6 is an important mediator of this induction. PMID: 23172820
    2. Vaccenic acid normalizes serum haptoglobin in obese/insulin resistant JCR:LA-cp rats PMID: 22254015
    3. activated glucocorticoid receptor through direct interactions with STAT3 and C/EBPbeta, participates in Hp gene upregulation as a transcriptional coactivator. PMID: 20155810
    4. Haptoglobin deficiency worsens intracerebral hemorrhage whereas haptoglobin overexpression alleviates intracerebral hemorrhage-mediated brain injury. PMID: 20016097
    5. Hp-mediated haemoglobin catabolism in lung cells may be an efficient mechanism to reduce oxidative damage associated with haemolysis PMID: 11865979
    6. Haptoglobin gene expression regulation PMID: 11865981
    7. Hp is transcriptionally modulated throughout prenatal hepatic development by fetal p53 protein. PMID: 11991649
    8. upregulated in reactive astrocytes after transient forebrain ischemia in rats PMID: 12368655
    9. Hp gene transcription is regulated by C/EBP alpha during normal liver development, whereas C/EBP beta is involved in the acute-phase response regulation during the later phase of differentiation and in the adult. PMID: 16172914
    10. Western blotting and enzyme-linked immunosorbent assay clearly showed a markedly increased level of Hp in the urine, but not in the serum, of the PHN animals. PMID: 17616219
    11. that interactions between C/EBPs and HDAC1 negatively regulate C/EBPdelta-dependent haptoglobin expression in intestinal epithelial cells. PMID: 17910034
    12. lamin components of the nuclear matrix form a network of functional, dynamic protein-protein and protein-Hp-S/MAR associations with multiple partners, and underline the involvement of PARP-1 in the regulation of haptoglobin gene transcription. PMID: 19521970
    13. Data concluded that haptoglobin gene up-regulation during chronic dietary restriction was regulated by different mechanisms than during the acute phase response. PMID: 19545490

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family
  • 組織特異性：
    Expressed by the liver and secreted in plasma.
  • 數(shù)據(jù)庫鏈接：

    KEGG: rno:24464

    UniGene: Rn.10950