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  4. Rat Cluster of Differentiation 63(CD63) ELISA Kit

Rat Cluster of Differentiation 63(CD63) ELISA Kit

  • 中文名稱：
    大鼠CD63分子酶聯免疫試劑盒
  • 貨號：
    CSB-E14117r
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 促銷：
  • 其他：

產品詳情

  • 產品描述：
    大鼠CD63分子酶聯免疫試劑盒（CSB-E14117r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CD63含量。CD63是一種跨膜糖蛋白，屬四次跨膜蛋白超家族成員。它在多種細胞的膜表面表達，具有參與細胞黏附、遷移等功能。研究機制上，其可能通過與其他分子相互作用，參與細胞內信號傳導過程，在腫瘤轉移、免疫調節等領域是研究熱點。試劑盒檢測范圍為62.5 pg/mL-4000 pg/mL，適用于神經退行性疾病模型、腫瘤微環境分析、炎癥機制研究等科研場景，為探索CD63在細胞外囊泡分泌、血小板活化或病理狀態下的功能調控提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Cd63; CD63 antigen; Mast cell antigen AD1; CD antigen CD63
  • 縮寫：
    CD63
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    62.5 pg/mL-4000 pg/mL
  • 靈敏度：
    15.6 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
  • 基因功能參考文獻：
    1. involved in extracellular matrix-basolateral membrane interactions PMID: 15504731
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Secreted, extracellular exosome. Cell surface.
  • 蛋白家族：
    Tetraspanin (TM4SF) family
  • 組織特異性：
    Detected in mast cells and platelets (at protein level).
  • 數據庫鏈接：