Mouse sex hormone-binding globulin,SHBG ELISA Kit

說明書下載

產品詳情

產品描述：

小鼠性激素結合球蛋白(SHBG)酶聯免疫試劑盒（CSB-E08233m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿樣本中的SHBG含量。SHBG即性激素結合球蛋白，它能特異性結合雄激素和雌激素，調控性激素在體內的活性。近年來研究發現其與多種疾病相關，如多囊卵巢綜合征、代謝綜合征等。深入研究其作用機制，或可助力相關疾病的早期診斷、病情評估及治療靶點開發。試劑盒檢測范圍為1.3 ng/mL-50 ng/mL，適用于研究性激素代謝調控機制、生殖系統疾病模型構建、內分泌干擾物評估等基礎科研場景，可滿足實驗室對小鼠生殖內分泌相關研究的定量檢測需求，為探索激素依賴性生理病理過程提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
別名：

Shbg ELISA Kit; Sex hormone-binding globulin ELISA Kit; SHBG ELISA Kit; Sex steroid-binding protein ELISA Kit; SBP ELISA Kit; Testis-specific androgen-binding protein ELISA Kit; ABP ELISA Kit
縮寫：

SHBG
Uniprot No.：

P97497
種屬：

Mus musculus (Mouse)
反應時間：

1-5h
上樣量：

50-100ul
檢測波長：

450 nm
研究領域：

Signal Transduction
測定原理：

quantitative
測定方法：

Sandwich
精密度：
線性度：
回收率：
標準曲線：
數據處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

功能：

Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
基因功能參考文獻：
1. SHBG suppresses inflammation and lipid accumulation in macrophages and adipocytes, which might be among the mechanisms underlying the protective effect of SHBG, that is, its actions which reduce the incidence of metabolic syndrome PMID: 30046278
2. A wave of apoptosis during the pre-pubertal period is required for normal spermatogenesis to develop, and our data indicate that this apoptotic wave may be regulated by ABP and/or androgens. PMID: 12831397
3. USF transcription factors repress SHBG transcription in Sertoli cells through an interaction with FP4 within its proximal promoter PMID: 15574421
4. monosaccharide-induced lipogenesis reduced hepatic HNF-4alpha levels, which in turn attenuated SHBG expression. PMID: 17992261
亞細胞定位：

Secreted.
數據庫鏈接：

KEGG: mmu:20415

STRING: 10090.ENSMUSP00000005334

UniGene: Mm.1431