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  4. Mouse monocyte chemotactic protein 2,MCP-2 ELISA kit

Mouse monocyte chemotactic protein 2,MCP-2 ELISA kit

  • 中文名稱：
    小鼠單核細胞趨化蛋白2(MCP-2/CCL8)酶聯免疫試劑盒
  • 貨號：
    CSB-E07428m
  • 規格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 促銷：
  • 其他：

產品詳情

  • 產品描述：
    小鼠單核細胞趨化蛋白2(MCP-2/CCL8)酶聯免疫試劑盒（CSB-E07428m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CCL8含量。CCL8是一個靶點。它屬于趨化因子家族，在炎癥反應、免疫調節等生理過程中發揮作用。研究機制方面，其可與相應受體結合，介導免疫細胞的遷移和活化，在腫瘤、自身免疫病等疾病進展中可能扮演重要角色，是潛在治療靶點。試劑盒檢測范圍為6.25 pg/mL-400 pg/mL，本試劑盒通過高特異性抗體對實現精準捕獲和信號放大，適用于小鼠模型中的炎癥機制研究、免疫調控實驗或相關疾?。ㄈ缱陨砻庖卟?、感染性疾病）的分子標志物分析，能夠穩定檢測生物樣本中低至皮克級別的目標蛋白含量，為科研人員探索趨化因子網絡功能提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Ccl8 ELISA Kit; Mcp2 ELISA Kit; Scya8C-C motif chemokine 8 ELISA Kit; Monocyte chemoattractant protein 2 ELISA Kit; Monocyte chemotactic protein 2 ELISA Kit; MCP-2 ELISA Kit; Small-inducible cytokine A8 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    6.25 pg/mL-400 pg/mL
  • 靈敏度：
    1.56 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse MCP-2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %87
    Range %85-88
    1:2Average %102
    Range %98-106
    1:4Average %98
    Range %96-101
    1:8Average %92
    Range %89-95
  • 回收率：
    The recovery of mouse MCP-2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8884-92
    EDTA plasma (n=4)9592-98
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    4002.955 2.781 2.868 2.720
    2002.138 2.156 2.147 1.999
    1001.445 1.532 1.489 1.341
    500.921 0.903 0.912 0.764
    250.584 0.561 0.573 0.425
    12.50.333 0.324 0.329 0.181
    6.250.241 0.253 0.247 0.099
    00.142 0.153 0.148
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Chemotactic factor that attracts monocytes. This protein can bind heparin.
  • 基因功能參考文獻：
    1. Findings exemplify how gradients of chemoattractive factors such as CCL8, drive metastasis and suggest that interference with their operation may provide means for breast cancer management. PMID: 27181207
    2. these data reveal an important role for BLIMP1 in modulating host defenses by suppressing expression of the chemokine CCL8. PMID: 24477914
    3. Results indicate that the induction of MCP-2/CCL8 by mycobacteria is dependent on the activation of TLR2/PI3K/Akt signaling pathway. PMID: 23418602
    4. Vitamin B6 supplementation downregulates Cd8a and Ccl8 mRNA expression, so these candidate genes may play a protective role against colonic aberrant crypt foci development. PMID: 22495988
    5. early and preclinical expression of CCL8 in plasma predicts overall survival of graft-vs.-host disease (GVHD) mice. Together with an involvement of allo-recognition in CCL8 expression, it suggests that CCL8 plays an important role in GVHD pathology. PMID: 21782767
    6. MCP/CCL8 was induced via STAT3 and exhibited anti-tumor metastatic effect PMID: 21624767
    7. promotes atopic dermatitis by recruiting IL-5+ Th2 cells PMID: 21217759
    8. CCL8 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli. PMID: 20931267
    9. Data show that that the stromal cell-derived chemokines CXCL12 and CCL8 cooperate to attract hematopoietic progenitors with the potential to differentiate into regulatory DCs. PMID: 20624948
    10. CCL8 is a promising specific serum marker for the early and accurate diagnosis of graft-versus-host disease. PMID: 18256320
    11. An elevated plasma CCL8 concentration may be a promising plasma marker for GVHD in mouse models PMID: 19302923

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 數據庫鏈接：


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