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  4. Mouse Eosinophil Peroxidase (EPO) ELISA Kit

Mouse Eosinophil Peroxidase (EPO) ELISA Kit

  • 中文名稱：
    小鼠嗜酸性粒細胞過氧化物酶(EPO)酶聯免疫試劑盒
  • 貨號：
    CSB-E15830m
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 促銷：
  • 其他：

產品詳情

  • 產品描述：
    小鼠嗜酸性粒細胞過氧化物酶(EPO)酶聯免疫試劑盒（CSB-E15830m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的EPX含量。小鼠嗜酸性粒細胞過氧化物酶（EPO）是一種調節骨代謝的關鍵酶，通過抑制破骨細胞和促進成骨細胞功能，維持骨穩態。其作用機制涉及降低破骨細胞活性氧水平，抑制RANK-MAPK信號通路，并可能影響成骨細胞分化和礦化。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，可助力探索嗜酸性粒細胞介導的免疫反應機制、評估實驗性炎癥模型中的細胞活化狀態，或用于藥物干預下EPO動態變化的監測，為免疫學、病理學及藥理學研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Epx ELISA Kit; Eper ELISA Kit; Eosinophil peroxidase ELISA Kit; EPO ELISA Kit; EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain] ELISA Kit
  • 縮寫：
    EPX
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse EPO in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %88
    Range %84-92
    1:2Average %94
    Range %90-98
    1:4Average %99
    Range %95-104
    1:8Average %102
    Range %98-107
  • 回收率：
    The recovery of mouse EPO spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9592-98
    EDTA plasma (n=4)9694-98
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    102.269 2.298 2.284 2.086
    51.674 1.698 1.686 1.488
    2.51.081 1.098 1.090 0.892
    1.250.729 0.769 0.749 0.551
    0.6250.437 0.457 0.447 0.249
    0.3120.388 0.363 0.376 0.178
    0.1560.283 0.303 0.293 0.095
    00.197 0.198 0.198 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils.
  • 基因功能參考文獻：
    1. The expression of MBP-1 and EPX was also required for induced lung expression of IL-4/IL-13 in each setting and, in turn, the induced pulmonary remodeling events and lung dysfunction. PMID: 28515227
    2. EPO-mediated protein carbamylation is promoted during allergen-induced asthma exacerbation, and can both modulate immune responses and trigger a cascade of many of the inflammatory signals present in asthma. PMID: 27587397
    3. The absence of MBP-1 and EPX promoted a concomitant loss of eosinophil lineage-committed progenitors in the marrow, identifying a specific blockade in eosinophilopoiesis as the causative event. PMID: 23736699
    4. HER2 was identified as a novel mediator of eosinophil peroxidase signaling. Eosinophil peroxidase, at noncytotoxic levels, can drive cell-cycle progression and proliferation. PMID: 21454806
    5. Host protection against Brugia pahangi infections was unimpaired in mice deficient in eosinophil peroxidase. PMID: 16299347
    6. Mice deficient for either eosinophil peroxidase or major basic protein on the 129/SvJ background developed significantly higher worm burdens than wild-type mice. PMID: 16926417
    7. post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase PMID: 18694936
    8. The activities of EPO, an eosinophilic secondary granule protein, do not affect the development of allergic pulmonary pathologies in the mouse lung at levels comparable to those observed in humans with asthma. PMID: 11466391

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  • 亞細胞定位：
    Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.
  • 蛋白家族：
    Peroxidase family, XPO subfamily
  • 數據庫鏈接：

    KEGG: mmu:13861

    STRING: 10090.ENSMUSP00000050497

    UniGene: Mm.1315



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