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Mouse Cadherin-3(CDH3) ELISA kit

  • 中文名稱:
    小鼠鈣黏蛋白3(CDH3)酶聯免疫試劑盒
  • 貨號:
    CSB-EL005052MO
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 促銷:
  • 其他:

產品詳情

  • 產品描述:
    小鼠鈣黏蛋白3(CDH3)酶聯免疫試劑盒(CSB-EL005052MO)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的CDH3含量。CDH3是一種重要靶點。其背景在于在多種生理與病理過程中發揮關鍵作用,尤其在腫瘤發生發展里常異常表達。研究機制方面,主要聚焦于其在細胞黏附、信號傳導等過程的作用,探索通過干預它來抑制腫瘤生長、轉移等的策略。試劑盒檢測范圍為78 pg/mL-5000 pg/mL,靈敏度為19.5 pg/mL。本試劑盒通過特異性抗體對實現高靈敏檢測,適用于小鼠模型中CDH3蛋白表達水平的動態監測,可廣泛用于腫瘤生物學、胚胎發育或炎癥微環境等領域的基礎研究。科研人員可通過深入探究CDH3在細胞遷移調控、上皮間質轉化等分子機制中的作用,為疾病相關信號通路研究提供可靠工具。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    Cdh3; Cdhp; Cadherin-3; Placental cadherin; P-cadherin
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    0.625 ng/ml-40 ng/ml
  • 靈敏度:
    0.156ng/ml
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Neuroscience
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
  • 基因功能參考文獻:
    1. P-Cadherin is not required for maintenance of retinal stem cells in vivo. PMID: 28494434
    2. P-cadherin (CDH3) is highly dominant in both mouse and human retinal pigment epithelium in situ. The degree of dominance of P-cadherin is surprisingly large, with mouse Cdh3 and human CDH3 accounting for 82-85% and 92-93% of the total of the three cadherin mRNAs, respectively. PMID: 29338041
    3. P-cadherin is a direct PAX3-FOXO1A transcriptional target involved in Alveolar rhabdomyosarcoma aggressiveness. PMID: 22710718
    4. Loss of P-cadherin is associated with melanoma. PMID: 21445019
    5. UVB exposure resulted in the overexpression of the cytokines, tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and the adhesion molecule P-cadherin. PMID: 20212509
    6. Truncated P-cadherin promotes melanoma cell invasion and migration and therefore has an important role in the progression of malignant melanoma. PMID: 16919267
    7. P-cadherin is a newly defined transcriptional target gene of p63, with a crucial role in hair follicle morphogenesis as well as the apical ectodermal ridge during limb bud outgrowth in humans whereas it is not required for either in mice. PMID: 18199584

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  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 數據庫鏈接:

    KEGG: mmu:12560

    STRING: 10090.ENSMUSP00000079613

    UniGene: Mm.4658



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