Monkey monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP1/MCAF ELISA kit

產品詳情

說明書下載

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.

產品描述：

猴子單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒（CSB-E10045Mo）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CCL2含量。CCL2 是一種趨化因子，廣泛參與炎癥反應、免疫調節(jié)等生理病理過程。其背景在于在多種疾病如腫瘤、炎癥性疾病中高表達。研究機制方面，它主要通過與受體結合，招募巨噬細胞等免疫細胞，在疾病發(fā)生發(fā)展進程中發(fā)揮重要作用。試劑盒檢測范圍為62.5 pg/mL-4000 pg/mL，適用于靈長類動物模型研究中MCP - 1表達水平的動態(tài)監(jiān)測，例如炎癥性疾病機制探索、免疫治療藥物效果評估或腫瘤微環(huán)境相關研究，為體外實驗中蛋白定量分析提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數(shù)及操作步驟詳見產品說明書。
別名：

CCL2 ELISA kit; MCP1 ELISA kit; SCYA2C-C motif chemokine 2 ELISA kit; Monocyte chemoattractant protein 1 ELISA kit; Monocyte chemotactic protein 1 ELISA kit; MCP-1 ELISA kit; Small-inducible cytokine A2 ELISA kit
縮寫：

CCL2
Uniprot No.：

P61275
種屬：

Monkey
樣本類型：

serum, plasma, tissue homogenates
檢測范圍：

62.5 pg/mL-4000 pg/mL
靈敏度：

15.6 pg/mL
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Immunology
測定原理：

quantitative
測定方法：

Sandwich

精密度：

標準曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

功能：

Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B.
亞細胞定位：

Secreted.
蛋白家族：

Intercrine beta (chemokine CC) family
數(shù)據(jù)庫鏈接：

KEGG: mcc:574138

STRING: 9544.ENSMMUP00000000391

UniGene: Mmu.3491