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  4. Human Immunoglobulin J chain(IGJ) ELISA kit

Human Immunoglobulin J chain(IGJ) ELISA kit

  • 中文名稱：
    人免疫球蛋白j鏈(Ig-j)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E09237h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 促銷：
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人免疫球蛋白j鏈(Ig-j)酶聯(lián)免疫試劑盒（CSB-E09237h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、唾液、尿液樣本中的IGJ含量。IGJ即免疫球蛋白J鏈，它參與分泌型免疫球蛋白的組裝與轉(zhuǎn)運。在研究機(jī)制上，其可調(diào)節(jié)免疫球蛋白多聚化，影響?zhàn)つっ庖吖δ堋GJ的深入研究有助于理解免疫相關(guān)疾病發(fā)病機(jī)制，為開發(fā)針對免疫調(diào)節(jié)的治療方法提供理論支持。試劑盒檢測范圍為10 ng/mL-40000 ng/mL，適用于科研領(lǐng)域中對黏膜免疫機(jī)制、感染性疾病或免疫缺陷相關(guān)研究，也可用于評估母乳喂養(yǎng)中免疫成分傳遞效率、淚液或唾液局部免疫狀態(tài)分析等實驗場景。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    IGCJ ELISA Kit; IGJ_HUMAN ELISA Kit; Immunoglobulin J chain ELISA Kit; Immunoglobulin J polypeptide linker protein for immunoglobulin alpha and mu polypeptides ELISA Kit; immunoglobulin joining chain ELISA Kit; JCH ELISA Kit; JCHAIN ELISA Kit; Joining chain of multimeric IgA and IgM ELISA Kit
  • 縮寫：
    IGJ
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, saliva, urine, tear, breast milk
  • 檢測范圍：
    10 ng/mL-40000 ng/mL
  • 靈敏度：
    10 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays):CV%<10%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human IGJ in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:1000 Average % 89    
    Range % 81-99    
    1:2000 Average % 95    
    Range % 83-99    
    1:4000 Average % 95    
    Range % 90-102    
    1:8000 Average % 90    
    Range % 85-100    
  • 回收率：
    The recovery of human IGJ spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 92 85-99    
    EDTA plasma (n=4) 95 90-100    
                   
                   
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    ng/ml OD1 OD2 Average Corrected    
    40000 2.257 2.242 2.250 2.162    
    10000 2.154 2.138 2.146 2.058    
    2500 1.892 1.864 1.878 1.790    
    625 1.252 1.249 1.251 1.163    
    156 0.587 0.598 0.593 0.505    
    39 0.282 0.288 0.285 0.197    
    10 0.141 0.139 0.140 0.052    
    0 0.086 0.090 0.088 　    
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component.
  • 基因功能參考文獻(xiàn)：
    1. TLR2 ligands induce CCR9 and CCR10 expression by circulating B-cells and increase their chemotaxis. TLR2 stimulation also induced J chain and IgA production demonstrating the induction of mucosal-like antibody secreting cells. PMID: 20947433
  • 亞細(xì)胞定位：
    Secreted.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5713

    OMIM: 147790

    KEGG: hsa:3512

    STRING: 9606.ENSP00000254801

    UniGene: Hs.643431