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  4. Human Annexin Ⅲ(ANX-Ⅲ) ELISA Kit

Human Annexin Ⅲ(ANX-Ⅲ) ELISA Kit

  • 中文名稱：
    人膜聯蛋白Ⅲ(ANX-Ⅲ)酶聯免疫試劑盒
  • 貨號：
    CSB-E12157h
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 促銷：
  • 其他：

產品詳情

  • 產品描述：
    人膜聯蛋白Ⅲ(ANX-Ⅲ)酶聯免疫試劑盒（CSB-E12157h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養上清液、組織勻漿、細胞裂解物樣本中的ANXA3含量。ANXA3是一種膜聯蛋白。它在多種病理生理過程中發揮作用。研究發現ANXA3可能參與細胞的增殖、凋亡及遷移等過程，還與腫瘤的發生發展、血管生成等存在關聯。其表達水平變化可能影響信號通路激活，以此調節細胞功能。試劑盒檢測范圍為0.78 ng/mL-50 ng/mL，適用于體外實驗中對心血管疾病、腫瘤微環境或炎癥相關疾病模型的分子機制研究，也可用于評估細胞應激狀態下ANX - Ⅲ的表達調控。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    2-cyclic phosphate 2-phosphohydrolase ELISA Kit; 35-alpha calcimedin ELISA Kit; Annexin A3 ELISA Kit; Annexin III ELISA Kit; Annexin-3 ELISA Kit; ANX3 ELISA Kit; ANXA 3 ELISA Kit; Anxa3 ELISA Kit; ANXA3_HUMAN ELISA Kit; Calcimedin 35 alpha ELISA Kit; Inositol 1 2 cyclic phosphate 2 phosphohydrolase ELISA Kit; Inositol 1 ELISA Kit; Lipocortin III ELISA Kit; OTTHUMP00000160701 ELISA Kit; OTTHUMP00000219237 ELISA Kit; OTTHUMP00000219238 ELISA Kit; PAP III ELISA Kit; PAP-III ELISA Kit; Placental anticoagulant protein III ELISA Kit
  • 縮寫：
    ANXA3
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cell culture supernates, tissue homogenates, cell lysates
  • 檢測范圍：
    0.78 ng/mL-50 ng/mL
  • 靈敏度：
    0.195 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human ANX-Ⅲin various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %95
    Range %92-101
    1:2Average %90
    Range %82-96
    1:4Average %101
    Range %99-104
    1:8Average %87
    Range %82-99
  • 回收率：
    The recovery of human ANX-Ⅲ spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9082-96
    EDTA plasma (n=4)9589-100
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    502.425 2.550 2.488 2.370
    252.010 2.174 2.092 1.974
    12.51.266 1.363 1.315 1.197
    6.250.559 0.597 0.578 0.460
    3.120.275 0.261 0.268 0.150
    1.560.192 0.186 0.189 0.071
    0.780.131 0.140 0.136 0.018
    00.122 0.113 0.118 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

平均分:
5.0分 - 1 個評價

樣品類型：血漿（抗凝劑） edta

樣品信息：人

稀釋比：沒有稀釋

產品評價： 我使用csb-e12157h進行檢測膿毒癥患者臨床血液標本，標本未經過稀釋處理，標準曲線好，結果膿毒癥患者血液標本中anxa3增多。試劑盒靈敏度好，很好用

By 梁老師

靶點詳情

  • 功能：
    Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.
  • 基因功能參考文獻：
    1. ANXA3 levels in urine show clinically significant correlation with real tumor volumes. PMID: 28703915
    2. The down-regulation of Annexin A3 by siRNA inhibited the invasion and epithelial-mesenchymal transition of colorectal cancer cells through the up-regulation of p53. PMID: 29224019
    3. ANXA3 plays important roles in gastric cancer carcinogenesis and metastasis. PMID: 27894078
    4. The findings implicate the expression of ANXA3 with the natural progression of breast cancer and associate it with increased lymphatic metastasis. The study validates the use of ANXA3 as a potential prognosis biomarker for breast cancer. PMID: 28497041
    5. we identified ANXA3 as a regulator of hepatitis C virus maturation and egress PMID: 27653686
    6. ANXA3 role in the proliferation and invasion of breast cancer cells. PMID: 27878264
    7. Results identified potential variant in ANXA3 gene [chr4, c.C820T(p.R274*)] in a large family with an unknown equinus deformity, which could lead to a three-dimensional conformational change. PMID: 27475959
    8. Anxa3 knockdown inhibited the growth, migration, invasion, and metastasis of lung adenocarcinoma. PMID: 27995049
    9. These results suggest that the iEA index or a combination of polymorphisms in EGFR and ANXA3 may serve as predictive factors of drug response, and therefore could be useful for optimal selection of chemotherapy regimens. PMID: 26475168
    10. ANX A3 has roles as a mammary biomarker, regulator and therapeutic target in breast cancer PMID: 26093083
    11. Our results suggest that ANXA3 can serve as a novel diagnostic biomarker and that the inhibition of ANXA3 may be a viable therapeutic option for the treatment of CD133+ liver-CSC-driven HCC. PMID: 26095609
    12. Findings reveal that ANXA3 might play an important role in hepatocellular carcinoma progression and chemoresistance. PMID: 24375474
    13. findings suggest that ANXA3 plays a role in HCC CSC/CIC maintenance, and that ANXA3 may represent a potential CSC/CIC-specific therapeutic target for improving the treatment of HCC. PMID: 25267273
    14. Two different antigenic variants of ANXA3 are present in post-DRE urines and their clinical significance for diagnosis of prostate cancer should be further investigated. PMID: 24954692
    15. Expression of annexin A3 was increased in gastric cancer compared with that in normal gastric tissues. Annexin A3 expression was significantly associated with tumor volume and TNM stage. PMID: 24815437
    16. Annexin A3 was upregulated in gastric cancer cells. Deletion of endogenous Annexin A3 significantly inhibited gastric cancer cell proliferation, migration, and invasion. PMID: 24824926
    17. Low ANXA3 expression is associated with radioresistance in nasopharyngeal carcinoma. PMID: 23464856
    18. Annexin A3 expression correlates with tumor size and lymph node metastasis.Annexin A3 might be regulated apoptosis by affecting Bcl-2/Bax balance.Annexin A3 was an independent prognostic factor in breast cancer. PMID: 23631820
    19. The expression change of Anxa3 can be utilized as a potential indicator for the development, invasion, metastasis and drug resistance of tumors. PMID: 23011854
    20. the association of multi-drug resistance with ANXA3, one of the highly expressed proteins in BEL7402/5-FU-resistant hepatoma cell line, was verified PMID: 22189913
    21. annexin A3 secretion may be associated with exocytosis and the release of exosomes PMID: 21435174
    22. Decreased expression of ANXA3 in papillary thyroid cancer supports the idea that ANXA3 may be an effective marker of microcarcinoma, and a negative predictor of papillary thyroid cancer progression. PMID: 21137070
    23. AnnexinA3 plays an important role in the initiation and progression of human gallbladder cancer. PMID: 21055154
    24. two spliced isoforms of Annexin A3 are expressed differently in human renal cortex and renal-cell carcinoma PMID: 20167856
    25. Annexin A3 could be a target for therapeutic intervention and may also serve as a biomarker for drug resistance in ovarian cancer patients. PMID: 20103635
    26. ANXA3 is a novel angiogenic factor that induces vascular endothelial growth factor production through the hypoxia-inducible factor-1 pathway PMID: 16236264

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  • 蛋白家族：
    Annexin family
  • 數據庫鏈接：

    HGNC: 541

    OMIM: 106490

    KEGG: hsa:306

    STRING: 9606.ENSP00000264908

    UniGene: Hs.480042



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